Cell culture as in vitro models for newly developed drugs against vector borne parasitic diseases within the One Health concept

Training School of the COST Action CA21111 One Health drugs against parasitic vector borne diseases in Europe and beyond OneHealthdrugs

Wednesday 25 September – Friday 27 September 2024 University of Warsaw, Warsaw, Poland 

Description. Newly developed pharmaceutical compounds need to meet specific safety and efficacy criteria before progressing to initial evaluations. In the initial study phase, a key step involves testing these compounds for toxicity and effectiveness in a controlled lab environment. 

The primary objective of this Training School is to conduct in vitro examinations, focusing on how selected compounds impact the survival of protozoan parasites and their ability to infect host cells. If the compounds hinder the parasites from multiplying within host cells, it is considered as an inhibitory effect of the pharmaceutical compound. Furthermore, the in vitro testing will assess the toxic effects of these pharmaceutical compounds on selected cell lines. The study of the drug's toxicity should also consider that the drug will be released into the environment. Therefore, evaluating its toxicity towards representative organisms in the ecosystem is essential. 

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Scientific Committee
Katarzyna Goździk

Anna Zawistowska Deniziak
Ewelina Kiernozek

Anabela Cordeiro da Silva

Maria Paola Costi
Sheraz Gul  

Organizing Committee
Katarzyna Goździk
Katarzyna Basałaj
Mateusz Pękacz
Ewelina Kiernozek 
Przemysław Wilkowski

Katarzyna Basałaj will be responsible for Science communication.