7th OHD Training School on SYNTHETIC CHEMISTRY OF ANTIMICROBIAL DRUGS AND PROTAC’S STRATEGY

Abstract

This training school offers an overview of one pivotal and emerging fields in modern medicinal chemistry: the synthesis of novel antimicrobial agents and example of the revolutionary PROTAC (Proteolysis-Targeting Chimera) strategy. In an era of escalating antimicrobial resistance, the demand for innovative therapeutic approaches is critical. This program will equip participants with the theoretical knowledge and practical insights necessary to address the synthetic aspects and the challenge.

The program is designed for early-career researchers, Ph.D. students, and post-doctoral fellows in medicinal chemistry, chemical biology, and related disciplines. Key topics will include advanced synthetic methodologies for developing new small-molecule antimicrobials, the fundamental principles of PROTAC design, and the application of this groundbreaking technology to combat infectious diseases. We will explore how PROTACs can redirect a cell’s own machinery to degrade disease-causing proteins, a paradigm-shifting approach that differs from traditional inhibition. The compounds design and synthesis will be in proposed in the context of greener approaches, including considerations for the ecotoxicity indicators.

Through lectures and interactive sessions, attendees will learn to critically evaluate potential drug targets and design molecules for both antimicrobial activity and targeted protein degradation. The goal of this training is to foster the next generation of drug discoverers by providing the skills needed to innovate and contribute to the fight against global health threats.

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