5TH OHD TRAINING SCHOOL - In silico prediction method for ecotoxicity and bioaccumulation

Motivation

Drug discovery is a complex process aiming to develop compounds with appropriate safety and efficacy profiles allowing to proceed to their clinical evaluation. Many of the drugs which are eventually approved are associated with ecotoxicity and bioaccumulation. In silico methods can be employed for predicting the ecotoxicity and bioaccumulation potential of chemicals, addressing environmental and regulatory concerns. These approaches employ mathematical models, databases, and algorithms to estimate the behaviour of compounds, without extensive laboratory testing, saving time, cost, and reducing animal testing.

This Training School aims to provide participants with a comprehensive understanding of in silico (computer-based) methods used to predict the ecotoxicity and bioaccumulation potential of chemicals. Through a series of lectures, hands-on workshops, and case studies, attendees will learn the principles, tools, and applications of computational techniques in environmental risk assessment. The training will cover key aspects such as predictive toxicology models, bioaccumulation forecasting, and the integration of in silico methods into environmental protection strategies. This event is designed for researchers and students seeking to enhance their knowledge in the field of environmental science and computational toxicology.

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Applications to the Training School can be made by submitting the Training School Application Form, together with a short Curriculum vitae (no longer than one page) and an endorsement letter from your supervisor or institutional head to Apostolia Zarmpala (azarmpala@cloudpharm.eu) with the e-mail subject CA21111 Training School Athens.

Application submission deadline: 03/02/2025.

The selection of participants will be made based on the quality of the above submitted documents with priority given to PhD Students and young researchers, alignment of research activities with the Training School Programme as well as country of affiliation, career stage and contributions to the OneHealthdrugs Cost Action.

Successful participants will be notified by 07/02/2025, who will need to create an e-COST account (https://e-services.cost.eu) after which they will receive an official invitation to the Training School.

Travel costs will be reimbursed for up to 15 participants. Reimbursement rules can be found in the ANNOTATED RULES FOR COST ACTIONS (https://www.cost.eu/uploads/2024/11/COST-094-21-V2.0-Annotated-Rules-for-COST-Actions-Level-C.pdf). Please carefully read this document as the reimbursement rules have been updated recently.