Adverse outcome pathways at early stages of the design of antiparasitic drugs 17th October 2024 - 9:00 am – 4:30 pm CET (VIRTUAL)

Adverse Outcome Pathways (AOPs) provide a framework for curating and organising toxicological & ecotoxicological knowledge with associated measurements of key events and the dose & temporal concordance of relationships between these events. AOPs have been the topic of many conferences and workshops since the concept was first proposed in 2012 when the Organisation for Economic Co-operation and Development (OECD) launched a new programme on the development of adverse outcome pathways. A guidance document that describes in detail how AOPs are to be developed, reviewed, agreed is published at the OECD level. To date these qualitative AOPs have made little impact in regulatory toxicology beyond chemical reactivity-driven endpoints. However, quantitative AOPs are likely to be significantly more impactful in next generation risk assessments using new approach methods without the need to conduct animal studies. There is, though little guidance on best practices for quantitative AOP generation. AOPs are important for expanding the use of mechanistic toxicological data for risk assessment and regulatory applications with recent applications in further disciplines such as climate science.

Our workshop has the objective to introduce to these concepts.

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Registration at the following link:

https://docs.google.com/forms/d/e/1FAIpQLSf4UlOIRg6YysU-J7QILUz-lEpD4oquRszJ20fJM3P8SHg_Og/viewform?usp=sharing